The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Novel strategy for non-invasive diagnosis of brain tumor patients

Illustration of vesivles in a cell. Drawing.
Created with BioRender.com

We explored how the proteome of secreted extracellular vesicles (EVs) may reflect hypoxic glioma cells and provided proof-of-concept for targeted proteomic profiling of glioma derived EVs as a new possible strategy for non-invasive diagnosis of glioblastoma.

This study provides a new strategy to comprehensively profile and monitor the hypoxic status of gliomas by exploring how the proteome of secreted extracellular vesicles (EVs) could reflect hypoxic glioma cells.

It is proposed, for the first time, that an EV protein signature could comprehensively reflect the hypoxic status of high-grade glioma cells by indicating molecular proximity to Mesenchymal subtypes, which should motivate future exploratory studies its utility in non-invasive diagnosis/monitoring of brain tumor patients.

Link to paper