Top 10 selected publications
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Governa V, Talbot H, Gonçalves de Oliveira K, Cerezo-Magaña M, Bång-Rudenstam A, Johansson MC, Månsson AS, Forsberg-Nilsson K, Marko-Varga G, Enríquez Pérez J, Darabi A, Malmström J, Bengzon J, Welinder C, Belting M. Landscape of surfaceome and endocytome in human glioma is divergent and depends on cellular spatial organization. Proceedings of the National Academy of Sciences USA. 2022; 119: e2114456119. Direct submission track.
We provide a novel strategy for global profiling of surface proteins as targets for immunotherapies directly in patient tissue and experimental 3D glioma models.
Cerezo-Magaña M, Christianson HC, van Kuppevelt TH, Forsberg-Nilsson K, Belting M. Hypoxic Induction of Exosome Uptake through Proteoglycan-Dependent Endocytosis Fuels the Lipid Droplet Phenotype in Glioma. Molecular Cancer Research. 2021; 19: 528-540.
We extend the multifaceted role of exosomes in glioma biology by showing their metabolism rewiring capacity in the hypoxic niche.
Indira Chandran V, Welinder C, Månsson AS, Offer S, Freyhult E, Pernemalm M, Lund SM, Pedersen S, Lehtiö J, Marko-Varga G, Johansson MC, Englund EM, Sundgren PC, Belting M. Ultrasensitive immunoprofiling of plasma extracellular vesicles identifies syndecan-1 as a potential tool for minimally invasive diagnosis of glioma. Clinical Cancer Research. 2019; 25: 3115-27.
We provide proof-of-concept for extracellular vesicle (EV) profiling as a strategy for non-invasive, liquid biopsy of brain tumors.
Offer S, Menard JA, Enríquez Pérez J, de Oliveira KG, Indira Chandran V, Johansson MC, Bång-Rudenstam A, Siesjö P, Ebbesson A, Hedenfalk I, Sundgren PC, Darabi A, Belting M. Extracellular lipid loading augments hypoxic paracrine signaling and promotes glioma angiogenesis and macrophage infiltration. Journal of Experimental & Clinical Cancer Research. 2019; 38: 241, 1-14.
Our findings high-light the role of lipid metabolism in the stressed GBM tumor niche.
Ek L,Gezelius E, Bergman B, Bendahl PO, Anderson H, Sundberg J, Wallberg M, Falkmer U, Verma S, Belting M. Randomized Phase III Trial of Low Molecular Weight Heparin Enoxaparin in Addition to Standard Treatment in Small Cell Lung Cancer: the RASTEN Trial. Annals of Oncology. 2018; 29: 398-404.
In this study, we translate original research findings into an international randomized, controlled phase-III, multi-center trial testing the anti-tumoral effect of LMWH in lung cancer.
Menard JA, Christianson HC, Kucharzewska P, Bourseau-Guilmain E, Svensson KJ, Lindqvist E, Chandran VI, Kjellén L, Welinder C, Bengzon J, Johansson MC, Belting M. Metastasis Stimulation by Hypoxia and Acidosis-Induced Extracellular Lipid Uptake Is Mediated by Proteoglycan Dependent Endocytosis. Cancer Research. 2016; 76: 4828-40.
We find that glioma tumors adapt to stress through increased recruitment of lipids, resulting in a lipid storing metabolic phenotype as a potentially targetable driver of tumor development.
Bourseau-Guilmain E, Menard JA, Lindqvist E, Indira Chandran V, Christianson HC, Cerezo Magaña M, Lidfeldt J, Marko-Varga G, Welinder C, Belting M. Hypoxia regulates global membrane protein endocytosis through caveolin-1 in cancer cells. Nature Communications. 2016; 20: 11371-83.
We for the first time show that stress conditions modulate surfaceome turnover in cancer cells, providing opportunities for tumor specific drug delivery.
Christianson HC, Svensson KJ, van Kuppevelt TH, Li JP, Belting M. Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity. Proceedings of the National Academy of Sciences USA. 2013; 110: 17380-5. Direct submission track.
In this highly cited paper, we identify heparan sulfate proteoglycan as a novel receptor and potential target for inhibition of exosome mediated glioma tumor development.
Kucharzewska P, Christianson HC, Welch JE, Svensson KJ, Fredlund E, Ringnér M, Mörgelin M, Bourseau-Guilmain E, Bengzon J, Belting M. Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development. Proceedings of the National Academy of Sciences USA. 2013; 110: 7312-7. Direct submission track.
In this highly cited paper we show that exosomes from glioma patients serve as a novel, non-invasive biomarker, and that exosomes constitute a potentially targetable mediator of tumor development.
- Svensson KJ, Kucharzewska P, Christianson HC, Sköld S, Löfstedt T, Johansson MC, Mörgelin M, Bengzon J, Ruf W, Belting M. Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2-mediated heparin-binding EGF signaling in endothelial cells. Proceedings of the National Academy of Sciences USA. 2011; 108: 13147-52. Direct submission track.
We find that hypoxic glioma cells release tissue factor (TF), i.e. the main initiator of coagulation, associated with exosomes that trigger angiogenesis in a paracrine manner.