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See here how lipid loading may be involved in the paracrine crosstalk between cancer cells and stromal compartment of the hypoxic tumor microenvironment.
In this paper, Belting Lab team and collaborators investigate the role of lipid loading effect o the cross-talk between cancer cells and the stromal compartment of hypoxic tumor niche.
The study shows that a lipid loaded niche can amplify the hypoxic response and reinforce activation of stormal and pro-tumorigenic immune cells.
