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Hypoxia modulates global membrane proteome turnover in cancer cells

Confocal microscopy image of cells stained for biotin and caveolin 1. Photo.

Hypoxia modulates global membrane proteome turnover in cancer cells, providing opportunities for tumor specific drug delivery.

Hypoxia promotes tumour aggressiveness and resistance of cancers to oncological treatment. The identification of cancer cell internalizing antigens for drug targeting to the hypoxic tumour niche remains a challenge of high clinical relevance. Here we show that hypoxia down-regulates the surface proteome at the global level and, more specifically, membrane proteome internalization. We find that hypoxic down-regulation of constitutive endocytosis is HIF-independent, and involves caveolin-1-mediated inhibition of dynamin-dependent, membrane raft endocytosis.